Recombinant humaan P-selectine

Source : Escherichia Coli. P-Selectin Human Recombinant is expressed in E. coli containing 566 amino acids 197-761 fused to an amino terminal hexahistidine tag. P-Selectin also called Platelet Alpha-Granule Membrane Protein, CD62, and Granulocyte Membrane Protein GRMP belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. Pselectin is expressed transiently on the surface of activated platelets and endothelial cells. P-Selectin is a 140 kDa protein which is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Secreted P-selectin is thought to play a key role in the adhesion of platelets to monocytes and neutrophils during an inflammatory response. P-Selectin is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Levels of P-Selectin may be elevated in a number of pathological conditions.

P-selectin||Granule membrane protein 140||GMP-140||PADGEM||Leukocyte-endothelial cell adhesion molecule 3||LECAM3||CD62 antigen-like family member P||CD62P antigen||SELP||GMRP||GRMP||CD62||PSEL||CD62P||GMP140||FLJ45155.

Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.

P-Selectin is supplied in 50% Glycerol.

Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.