Recombinant humaan PD-1-eiwit

PDCD1, also known as programmed cell death protein 1, is a type 1 transmembrane glycoprotein, and is an immune-receptor belonging to the CD28/CTLA4 family. This protein is expressed on the surface of activated T-cell, B-cell, macrophages, myeloid cells and subset of thymocytes. Also, it inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4 and IL-10. As a cell surface molecule, it regulates the adaptive immune response. Recombinant human PDCD1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Programmed cell death protein 1, PDCD1, CD279, hPD-1, hPD-l, hSLE1, PD-1, PD1, SLEB2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

44 kDa (392aa)

PD1, Programmed cell death protein 1, PDCD1, CD279, hPD-1, hPD-l, hSLE1, PD-1, PD1, SLEB2, PD-1, PD1 protein, ATGP3612-10 µg, ATGP3612-20 µg, ATGP3612-50 µg, ATGP3612-100 µg, ATGP3612-250 µg, ATGP3612-500 µg, ATGP3612-1 mg, ATGP3612-10, ATGP3612-20, ATGP3612-50, ATGP3612-100, ATGP3612-250, ATGP3612-500, ATGP3612-1

Ishida Y., et al, (1992) EMBO J. 11:3887-3895.; ; Lastwika KJ., et al, (2016) Cancer Res. 76:227-238.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

NP_005009.2

Q15116

Human

Ala

PGWFLDS PDRPWNPPTF SPALLVVTEG DNATFTCSFS NTSESFVLNW YRMSPSNQTD KLAAFPEDRS QPGQDCRFRV TQLPNGRDFH MSVVRARRND SGTYLCGAIS LAPKAQIKES LRAELRVTER RAEVPTAHPS PSPRPAGQFQ TLV