Recombinant humaan PD-L2/B7-DC-eiwit

PDCD1LG2, also known as programmed cell death 1 ligand 2, which belongs to the immunoglobulin superfamily or TN/MOG family. This protein is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Also, it interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Recombinant human PDCD1LG2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Programmed cell death 1 ligand 2, PDCD1LG2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

47.7 kDa (423aa)

PD-L2, B7-DC, Programmed cell death 1 ligand 2, PDCD1LG2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2, ATGP3571-10 µg, ATGP3571-20 µg, ATGP3571-50 µg, ATGP3571-100 µg, ATGP3571-250 µg, ATGP3571-500 µg, ATGP3571-1 mg, ATGP3571-10, ATGP3571-20, ATGP3571-50, ATGP3571-100, ATGP3571-250, ATGP3571-500, ATGP3571-1

Xu J., et al, (2016) Am. J. Surg. Pathol. 40:443-453.; ; Latchman Y., et al, (2001) Nat. Immunol. 2:261-268.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_079515

Q9BQ51

Human

Ala

ADPLFTVTVP KELYIIEHGS NVTLECNFDT GSHVNLGAIT ASLQKVENDT SPHRERATLL EEQLPLGKAS FHIPQVQVRD EGQYQCIIIY GVAWDYKYLT LKVKASYRKI NTHILKVPET DEVELTCQAT GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVRLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH