Recombinant humaan PDGF R bèta-eiwit

PDGFRB, also known as platelet-derived growth factor receptor beta, is a member of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3-ligand. It plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. It promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. It phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Recombinant human PDGFRB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Platelet-derived growth factor receptor beta, PDGFRB, CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

83.3 kDa (739aa)

PDGF R b, Platelet-derived growth factor receptor beta, PDGFRB, CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, ATGP3721-10 µg, ATGP3721-20 µg, ATGP3721-50 µg, ATGP3721-100 µg, ATGP3721-250 µg, ATGP3721-500 µg, ATGP3721-1 mg, ATGP3721-10, ATGP3721-20, ATGP3721-50, ATGP3721-100, ATGP3721-250, ATGP3721-500, ATGP3721-1

Kelly JD., et al. (1991) J Biol Chem. 266:8987-8992.; ; Kashishian A., et al. (1992) EMBO J. 11:1373-1382.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_002600

P09619

Human

Leu33