Recombinant humaan PEX26-eiwit

PEX26 belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8) . PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP) . Alternatively spliced transcript variants have been identified for this gene. Recombinant human PEX26 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Peroxisome assembly protein 26, PBD7A, PBD7B, PEX26M1T, Pex26pM1T

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

29.3 kDa (269aa) confirmed by MALDI-TOF

PEX26, Peroxisome assembly protein 26, PBD7A, PBD7B, PEX26M1T, Pex26pM1T, ATGP2196-10 µg, ATGP2196-20 µg, ATGP2196-50 µg, ATGP2196-100 µg, ATGP2196-250 µg, ATGP2196-500 µg, ATGP2196-1 mg, ATGP2196-10, ATGP2196-20, ATGP2196-50, ATGP2196-100, ATGP2196-250, ATGP2196-500, ATGP2196-1

Matsumoto N., et al. (2003) Nat. Cell Biol. 5:454-460; ; Matsumoto N., et al. (2003) Am. J. Hum. Genet. 73:233-246;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT

Signal Transduction

NP_001121121

Q7Z412

Human

MKSDSST SAAPLRGLGG PLRSSEPVRA VPARAPAVDL LEEAADLLVV HLDFRAALET CERAWQSLAN HAVAEEPAGT SLEVKCSLCV VGIQALAEMD RWQEVLSWVL QYYQVPEKLP PKVLELCILL YSKMQEPGAV LDVVGAWLQD PANQNLPEYG ALAEFHVQRV LLPLGCLSEA EELVVGSAAF GEERRLDVLQ AIHTARQQQK QEHSGSEEAQ KPNLEGSVSH KFLSLPMLVR QLWDSAVSH