Recombinant humaan PGM1-eiwit

PGM1 also known as Phosphoglucomutase-1 isoform 1. PGM1 belongs to the phosphohexose mutase family. There are several PGM isozymes, which are catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, PGM1 isozymes predominate, representing about 90% of total PGM activity. Defects in PGM1 are the cause of glycogen storage disease type 14. Recombinant human PGM1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques

Phosphoglucomutase-1 isoform 1, CDG1T, GSD14

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

> 95% by SDS-PAGE

63.8 kDa (585aa)

PGM1, Phosphoglucomutase-1 isoform 1, CDG1T, GSD14, ATGP3158-10 µg, ATGP3158-20 µg, ATGP3158-50 µg, ATGP3158-100 µg, ATGP3158-250 µg, ATGP3158-500 µg, ATGP3158-1 mg, ATGP3158-10, ATGP3158-20, ATGP3158-50, ATGP3158-100, ATGP3158-250, ATGP3158-500, ATGP3158-1

Gururaj A., et al (2004) . Oncogene. 23 (49) :8118-27.; ; Stojkovic T., et al (2009) . N. Engl. J. Med. 361 (4) :425-7.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Metabolism

NP_002624

P36871

Human

MGSSHHHHHH SSGLVPRGSH MGSMVKIVTV KTQAYQDQKP GTSGLRKRVK VFQSSANYAE NFIQSIISTV EPAQRQEATL VVGGDGRFYM KEAIQLIARI AAANGIGRLV IGQNGILSTP AVSCIIRKIK AIGGIILTAS HNPGGPNGDF GIKFNISNGG PAPEAITDKI FQISKTIEEY AVCPDLKVDL GVLGKQQFDL ENKFKPFTVE IVDSVEAYAT MLRSIFDFSA LKELLSGPNR LKIRIDAMHG VVGPYVKKIL CEELGAPANS AVNCVPLEDF GGHHPDPNLT YAADLVETMK SGEHDFGAAF DGDGDRNMIL GKHGFFVNPS DSVAVIAANI FSIPYFQQTG VRGFARSMPT SGALDRVASA TKIALYETPT GWKFFGNLMD ASKLSLCGEE SFGTGSDHIR EKDGLWAVLA WLSILATRKQ SVEDILKDHW QKYGRNFFTR YDYEEVEAEG ANKMMKDLEA LMFDRSFVGK QFSANDKVYT VEKADNFEYS DPVDGSISRN QGLRLIFTDG SRIVFRLSGT GSAGATIRLY IDSYEKDVAK INQDPQVMLA PLISIALKVS QLQERTGRTA PTVIT