Recombinant humaan PINK1-eiwit

PINK1 is a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this protein cause one form of autosomal recessive early-onset Parkinson disease. Recombinant human PINK protein was expressed in E. coli and purified by using conventional chromatography techniques.

Serine/threonine-protein kinase PINK1 mitochondrial, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, FLJ27236, PARK6

E.coli

Human

Non-Tagged

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

37.9 kDa (353aa)

PINK1, Serine/threonine-protein kinase PINK1 mitochondrial, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, FLJ27236, PARK6, ATGP1240-10 µg, ATGP1240-20 µg, ATGP1240-50 µg, ATGP1240-100 µg, ATGP1240-250 µg, ATGP1240-500 µg, ATGP1240-1 mg, ATGP1240-10, ATGP1240-20, ATGP1240-50, ATGP1240-100, ATGP1240-250, ATGP1240-500, ATGP1240-1

Valente EM., et al. (2004) Ann Neurol. 56 (3) :336-41.; ; unoki M., et al. (2001) Oncogene. 20 (33) :4457-65.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) 1M urea, 5% glycerol

Neuroscience

AAH28215

Q9BXM7

Human

MYLIGQSIGK GCSAAVYEAT MPTLPQNLEV TKSTGLLPGR GPGTSAPGEG QERAPGAPAF PLAIKMMWNI SAGSSSEAIL NTMSQELVPA SRVALAGEYG AVTYRKSKRG PKQLAPHPNI IRVLRAFTSS VPLLPGALVD YPDVLPSRLH PEGLGHGRTL FLVMKNYPCT LRQYLCVNTP SPRLAAMMLL QLLEGVDHLV QQGIAHRDLK SDNILVELDP DGCPWLVIAD FGCCLADESI GLQLPFSSWY VDRGGNGCLM APEVSTARPG PRAVIDYSKA DAWAVGAIAY EIFGLVNPFY GQGKAHLESR SYQEAQLPAL PESVPPDVRQ LVRALLQREA SKRPSARVAA NVL