Recombinant humaan PINX1-eiwit

PINX1 (PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

PIN2-interacting protein 1, PIN2-interacting protein 1, TRF1-interacting protein 1, Liver-related putative tumor suppressor, Protein 67-11-3, LPTL, LPTS, PINX1, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1, Hepatocellular carcinoma-related putative tumor suppressor

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

39.1 kDa (348aa) confirmed by MALDI-TOF

PINX1, PIN2-interacting protein 1, PIN2-interacting protein 1, TRF1-interacting protein 1, Liver-related putative tumor suppressor, Protein 67-11-3, LPTL, LPTS, PINX1, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1, Hepatocellular carcinoma-related putative tumor suppressor, ATGP0310-10 µg, ATGP0310-20 µg, ATGP0310-50 µg, ATGP0310-100 µg, ATGP0310-250 µg, ATGP0310-500 µg, ATGP0310-1 mg, ATGP0310-10, ATGP0310-20, ATGP0310-50, ATGP0310-100, ATGP0310-250, ATGP0310-500, ATGP0310-1

Zhou XZ., et al. (2001) . Cell. 107 (3) :347-59; ; Yoo JE., et al. (2009) . J Mol Biol. 388 (5) :928-40;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing, 1mM DTT, 10% glycerol

Cancer

NP_060354

Q96BK5

Human

MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK