Recombinant humaan PMEL-eiwit met C-terminaal humaan Fc-tag

Expression Host : HEK293 The protein has a predicted molecular mass of 46.2 kDa after removal of the signal peptide.The apparent molecular mass of PMEL-hFc is approximately 130-250 kDa due to glycosylation. This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

D12S53E, gp100, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Delivery in 1-2 weeks

Store at -80°C for 12 months (Avoid repeated freezing and thawing)