Recombinant humaan Prohibitine 2-eiwit

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases by similarity. This protein functions as an estrogen receptor (ER) -selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging. Recombinant human PHB2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Prohibitin 2, Bap37, p22, B cell receptor associated protein 37, BAP, BCAP37, PNAS-141, REA, PHB2

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

35.7 kDa (322aa)

B cell receptor associated protein 37, BAP, BAP 37, BAP37, BCAP 37, BCAP37, p22, PHB2, PNAS 141, PNAS141, PNAS-141, Prohibitin 2, Prohibitin2, REA, ATGP2184-10 µg, ATGP2184-20 µg, ATGP2184-50 µg, ATGP2184-100 µg, ATGP2184-250 µg, ATGP2184-500 µg, ATGP2184-1 mg, ATGP2184-010, ATGP2184-020, ATGP2184-050, ATGP2184-100, ATGP2184-250, ATGP2184-500, ATGP2184-01M

Kategaya, L.S., et al. (2012) PLoS ONE 7 (2), E31987; ; Emerson, V., et al. (2010) J. Virol. 84 (3), 1355-1365

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol

Signal Transduction

NP_001138303.1

Q99623

Human

MAQNLKD LAGRLPAGPR GMGTALKLLL GAGAVAYGVR ESVFTVEGGH RAIFFNRIGG VQQDTILAEG LHFRIPWFQY PIIYDIRARP RKISSPTGSK DLQMVNISLR VLSRPNAQEL PSMYQRLGLD YEERVLPSIV NEVLKSVVAK FNASQLITQR AQVSLLIRRE LTERAKDFSL ILDDVAITEL SFSREYTAAV EAKQVAQQEA QRAQFLVEKA KQEQRQKIVQ AEGEAEAAKM LGEALSKNPG YIKLRKIRAA QNISKTIATS QNRIYLTADN LVLNLQDESF TRGSDSLIKG KK