Recombinant humaan PSG1-eiwit

PSG1 belongs to a subgroup of transcription factors that are phosphorylated upon binding to promoter sequences. PSGs are part of the carcinoembryonic antigen (CEA) family and serve as early biochemical markers of syncytiotrophoblast formation. The sequence specificity of DNA binding is conferred by Zn (II) fingers, whereas a different region of PSG1 appears to regulate the affinity of DNA binding. Additionally, PSG1 is believed to mediate placental vascular morphogenesis by enhancing VEGF-A production and endothelial tube formation. Recombinant human PSG1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Pregnancy-specific beta-1-glycoprotein 1 isoform 1, Pregnancy-specific beta-1-glycoprotein 1 isoform 1, B1G1, CD66f, DHFRP2, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1, PSBG-1, PSBG1, PSG95, PSGGA, PSGIIA, SP1

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

45.9 kDa (408aa)

PSG1, Pregnancy-specific beta-1-glycoprotein 1 isoform 1, Pregnancy-specific beta-1-glycoprotein 1 isoform 1, B1G1, CD66f, DHFRP2, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1, PSBG-1, PSBG1, PSG95, PSGGA, PSGIIA, SP1, ATGP2682-10 µg, ATGP2682-20 µg, ATGP2682-50 µg, ATGP2682-100 µg, ATGP2682-250 µg, ATGP2682-500 µg, ATGP2682-1 mg, ATGP2682-10, ATGP2682-20, ATGP2682-50, ATGP2682-100, ATGP2682-250, ATGP2682-500, ATGP2682-1

Liu H., et al. (2002) Mol Cell Biol. 22: 6471-6479.; ; Van der Watt P J., et al. (2011) Biochim Biophys Acta. 1809: 316-326.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Other

NP_008836

P11464

Human

MGSSHHHHHH SSGLVPRGSH MGSQVTIEAE PTKVSEGKDV LLLVHNLPQN LTGYIWYKGQ MRDLYHYITS YVVDGEIIIY GPAYSGRETA YSNASLLIQN VTREDAGSYT LHIIKGDDGT RGVTGRFTFT LHLETPKPSI SSSNLNPRET MEAVSLTCDP ETPDASYLWW MNGQSLPMTH SLKLSETNRT LFLLGVTKYT AGPYECEIRN PVSASRSDPV TLNLLPKLPK PYITINNLNP RENKDVLNFT CEPKSENYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT RNETGPYQCE IRDRYGGIRS DPVTLNVLYG PDLPRIYPSF TYYRSGEVLY LSCSADSNPP AQYSWTINEK FQLPGQKLFI RHITTKHSGL YVCSVRNSAT GKESSKSMTV EVSGKWIP