Recombinant humaan RAB24-eiwit

RAB24 belongs to the small GTPase superfamily. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of RAB24 remains unknown. RAB24 is distributed in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures, and this subcellular distribution pattern of RAB24 may indicate its involvement in autophagy-related processes. RAB24 presents unusual characteristics, including low intrinsic GTPase activity, and is inefficiently prenylated when compared with other Rab proteins. Also suggested that RAB24 might play a unique role in the degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope. Recombinant human RAB24 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Ras-related protein Rab-24, RAB24 member RAS oncogene family

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

25.6 kDa (227aa) confirmed by MALDI-TOF

RAB24, Ras-related protein Rab-24, ATGP1247-10 µg, ATGP1247-20 µg, ATGP1247-50 µg, ATGP1247-100 µg, ATGP1247-250 µg, ATGP1247-500 µg, ATGP1247-1 mg, ATGP1247-10, ATGP1247-20, ATGP1247-50, ATGP1247-100, ATGP1247-250, ATGP1247-500, ATGP1247-1

Maltese WA, et al. (2002) BMC Cell Biol. 3:25.; ; Wu M, Yin G, et al. (2006) Int J Mol Med. 17 (5) :749-54.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 30% glycerol, 100 mM NaCl, 1mM EDTA

Signal Transduction

NP_570137

Q969Q5

Human

MSGQRV DVKVVMLGKE YVGKTSLVER YVHDRFLVGP YQNTIGAAFV AKVMSVGDRT VTLGIWDTAG SERYEAMSRI YYRGAKAAIV CYDLTDSSSF ERAKFWVKEL RSLEEGCQIY LCGTKSDLLE EDRRRRRVDF HDVQDYADNI KAQLFETSSK TGQSVDELFQ KVAEDYVSVA AFQVMTEDKG VDLGQKPNPY FYSCCHH