Recombinant humaan RAB27A-eiwit

Ras-related protein Rab-27A, also known as RAB27A, belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Also, RAB27A regulates the cytotoxic granule exocytosis and affect T-lymphocyte and macrophage-activation. It is widely expressed with significant expression in pancreatic islets and pituitary tissue, and low expression in brain. Defects in RAB27A cause Griscelli syndrome type 2 (GS2) . Recombinant human RAB27A, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Ras-related protein Rab-27A, GS2, RAM, RAB27, Ras-related protein Rab-27A GTP-binding protein Ram, HsT18676.MGC117246, Rab-27, RAB27A, member RAS oncogene family, Ras-related protein Rab27A.

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

27 kDa (241aa) confirmed by MALDI-TOF

Rab27a, Ras-related protein Rab-27A, GS2, RAM, RAB27, Ras-related protein Rab-27A GTP-binding protein Ram, HsT18676.MGC117246, Rab-27, RAB27A, member RAS oncogene family, Ras-related protein Rab27A., ATGP0556-10 µg, ATGP0556-20 µg, ATGP0556-50 µg, ATGP0556-100 µg, ATGP0556-250 µg, ATGP0556-500 µg, ATGP0556-1 mg, ATGP0556-10, ATGP0556-20, ATGP0556-50, ATGP0556-100, ATGP0556-250, ATGP0556-500, ATGP0556-1

Kuroda TS., et al. (2002) J Biol Chem. 277 (11) :9212-8.; ; Barral DC., et al. (2002) J Clin Invest. 110:61-5.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Cancer

NP_899059

P51159

Human

MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C