Recombinant humaan RAB7A-eiwit

Ras-related protein Rab-7a, also known as RAB7A, is a member of the Ras superfamily of small Rab GTPases. RAB7A associates with the RIPL effector protein to control membrane trafficking from early to late endosome and to lysosomes. RAB7A has also been shown to regulate growth receptor endocytic trafficking, degradation, maturation of phagosome and autophagic vacuoles. Recombinant human RAB7A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Ras-related protein Rab-7a, RAB7, RAB7A member RAS oncogene family, CMT2B, Charcot-Marie-Tooth neuropathy 2B

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

25.6 kDa (227aa) confirmed by MALDI-TOF

Rab7a, Ras-related protein Rab-7a, RAB7, ATGP0877-10 µg, ATGP0877-20 µg, ATGP0877-50 µg, ATGP0877-100 µg, ATGP0877-250 µg, ATGP0877-500 µg, ATGP0877-1 mg, ATGP0877-10, ATGP0877-20, ATGP0877-50, ATGP0877-100, ATGP0877-250, ATGP0877-500, ATGP0877-1

Feng Y., et al. (1995) J Cell Biol. 131:1435-52.; ; Barbero P., et al. (2002) J Cell Biol. 156:511-8.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 100 mM NaCl

Signal Transduction

NP_004628.4

P51149

Human

MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKA SAESCSC