Recombinant humaan RASSF1A-eiwit

RASSF1A is similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. This protein required for death receptor-dependent apoptosis. Recombinant human RASSF1A protein, fused to His-tag at N-terminus, was expressed in E. coli.

Ras association domain-containing protein 1, 123F2, NORE2A, RASSF1, RDA32, REH3P21

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

42.9 kDa (376aa)

RASSF1A, Ras association domain-containing protein 1, 123F2, NORE2A, RASSF1, RDA32, REH3P21, ATGP1815-10 µg, ATGP1815-20 µg, ATGP1815-50 µg, ATGP1815-100 µg, ATGP1815-250 µg, ATGP1815-500 µg, ATGP1815-1 mg, ATGP1815-10, ATGP1815-20, ATGP1815-50, ATGP1815-100, ATGP1815-250, ATGP1815-500, ATGP1815-1

Burbee D.G., et al. (2001) J. Natl. Cancer Inst. 93:691-699; ; Shivakumar L., et al. (2002) Mol. Cell. Biol. 22:4309-4318;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Cancer

NP_009113

Q9NS23

Human

MSGE PELIELRELA PAGRAGKGRT RLERANALRI ARGTACNPTR QLVPGRGHRF QPAGPATHTW CDLCGDFIWG VVRKGLQCAH CKFTCHYRCR ALVCLDCCGP RDLGWEPAVE RDTNVDEPVE WETPDLSQAE IEQKIKEYNA QINSNLFMSL NKDGSYTGFI KVQLKLVRPV SVPSSKKPPS LQDARRGPGR GTSVRRRTSF YLPKDAVKHL HVLSRTRARE VIEALLRKFL VVDDPRKFAL FERAERHGQV YLRKLLDDEQ PLRLRLLAGP SDKALSFVLK ENDSGEVNWD AFSMPELHNF LRILQREEEE HLRQILQKYS YCRQKIQEAL HACPLG