Recombinant humaan RGN-eiwit

RGN (Regucalcin) belongs to the SMP-30/CGR1 family. This protein is Ca (2+) -binding protein that does not contain EF-hand motif of Ca (2+) -binding domain. RGN plays a pivotal role in the keep of intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane (basolateral membrane), microsomes (endoplasmic reticulum) and mitochondria of many cells. Also, it plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain and a suppressor protein for cell signaling systems in many cell types.

Regucalcin, RC, SMP30

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

35.4 kDa (319aa)

RGN, Regucalcin, RC, SMP30, ATGP1187-10 µg, ATGP1187-20 µg, ATGP1187-50 µg, ATGP1187-100 µg, ATGP1187-250 µg, ATGP1187-500 µg, ATGP1187-1 mg, ATGP1187-10, ATGP1187-20, ATGP1187-50, ATGP1187-100, ATGP1187-250, ATGP1187-500, ATGP1187-1

Chakraborti S., et al. (2010) Biochemistry. 49:3436-3444; ; Yamaguchi M., et al. (2005) Int J Mol Med. 15: 372-389

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% glycerol

Signal Transduction

NP_690608

Q15493

Human

MSSIKIECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG