Recombinant humaan S100A8-eiwit

S100 calcium binding protein A8, also known as MRP8, is a member of the S100 family, EF-hand superfamily of Calcium binding proteins. S100A8 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Altered expression of this protein is associated with the disease cystic fibrosis. Recombinant human S100A8 was expressed in E. coli and purified by using conventional chromatography techniques.

S100 calcium binding protein A8, Calgranulin-A, MRP-8, CFAG, CAGA, S100 calcium binding protein A8 60B8Ag, AI323541, B8Ag, BEE11, CAGA, Calprotectin L1L subunit, Calprotectin, included, CGLA, Chemotactic cytokine CP-10, CP-10, Cystic fibrosisantigen, L1Ag, Leukocyte L1 complex light chain, MA387, MIF, Migration inhibitory factor-related protein 8, Myeloid-related protein 8, Neutrophil cytosolic 7 kDa protein, NIF, p8, Pro-inflammatory S100 cytokine, Protein S100-A8, S100 calcium binding protein A8 (calgranulin A), S100A8, S100A8/S100A9 complex, included, urinary stone protein band A.

E.coli

Human

Non-Tagged

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

> 90% by SDS-PAGE

10.8 Da (93aa) confirmed by MALDI-TOF

S100A8, S100 calcium binding protein A8, Calgranulin-A, MRP-8, CFAG, CAGA, S100 calcium binding protein A8 60B8Ag, AI323541, B8Ag, BEE11, CAGA, Calprotectin L1L subunit, Calprotectin, included, CGLA, Chemotactic cytokine CP-10, CP-10, Cystic fibrosisantigen, L1Ag, Leukocyte L1 complex light chain, MA387, MIF, Migration inhibitory factor-related protein 8, Myeloid-related protein 8, Neutrophil cytosolic 7 kDa protein, NIF, p8, Pro-inflammatory S100 cytokine, Protein S100-A8, S100 calcium binding protein A8 (calgranulin A), S100A8, S100A8/S100A9 complex, included, urinary stone protein band A., ATGP0524-10 µg, ATGP0524-20 µg, ATGP0524-50 µg, ATGP0524-100 µg, ATGP0524-250 µg, ATGP0524-500 µg, ATGP0524-1 mg, ATGP0524-10, ATGP0524-20, ATGP0524-50, ATGP0524-100, ATGP0524-250, ATGP0524-500, ATGP0524-1

Kerkhoff C., et al. (1999) Biochim. Biophys. 1448 (2) :200-11. ; ; Nacken W., et al. (2003) Biochim. Biophys. 60 (6) :569-80.;

Kwon CH, et al. S100A8 and S100A9 Promotes Invasion and Migration through p38 Mitogen-Activated Protein kinase-Dependent NF-kB Activation in Gastric Cancer Cells. (Mol Cells. 2013) {https://pubmed.ncbi.nlm.nih.gov/23456298/}; ; Nishikawa Y, et al. Calprotectin Induces IL-6 and MCP-1 Production via Toll-Like Receptor 4 Signaling in Human Gingival Fibroblasts. (J Cell Physiol. 2017) {https://pubmed.ncbi.nlm.nih.gov/27925202/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Cancer

NP_002955.2

P05109

Human

MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE