Recombinant humaan Serpin C1/Antitrombine-III eiwit

Antithrombin-III precursor, also known as SERPINC1, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The inhibitory activity of SERPINC1 is amplified in the presence of heparin. SERPINC1 inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia. Recombinant human SERPINC1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Antithrombin-III precursor, AT3, AT3D, ATIII, THPH7

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

51.4 kDa (455aa)

Serpin C1, Antithrombin-3, Antithrombin-III precursor, AT3, AT3D, ATIII, THPH7, ATGP2571-10 µg, ATGP2571-20 µg, ATGP2571-50 µg, ATGP2571-100 µg, ATGP2571-250 µg, ATGP2571-500 µg, ATGP2571-1 mg, ATGP2571-10, ATGP2571-20, ATGP2571-50, ATGP2571-100, ATGP2571-250, ATGP2571-500, ATGP2571-1

Yeung P K., et al. (2000) IDrugs. 37: 669-673.; ; Okajima K., et al. (1995) Am J Hematol. 48: 12-18.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Cardiovascular

NP_000479

P01008

Human

HGSPVDI CTAKPRDIPM NPMCIYRSPE KKATEDEGSE QKIPEATNRR VWELSKANSR FATTFYQHLA DSKNDNDNIF LSPLSISTAF AMTKLGACND TLQQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SKLVSANRLF GDKSLTFNET YQDISELVYG AKLQPLDFKE NAEQSRAAIN KWVSNKTEGR ITDVIPSEAI NELTVLVLVN TIYFKGLWKS KFSPENTRKE LFYKADGESC SASMMYQEGK FRYRRVAEGT QVLELPFKGD DITMVLILPK PEKSLAKVEK ELTPEVLQEW LDELEEMMLV VHMPRFRIED GFSLKEQLQD MGLVDLFSPE KSKLPGIVAE GRDDLYVSDA FHKAFLEVNE EGSEAAASTA VVIAGRSLNP NRVTFKANRP FLVFIREVPL NTIIFMGRVA NPCVK