Recombinant humaan SH2D1A-eiwit

SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease. XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection. Recombinant human SH2D1A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

SH2 domain-containing protein 1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

16.3 kDa (148aa) confirmed by MALDI-TOF

SH2D1A, SH2 domain-containing protein 1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD, ATGP0783-10 µg, ATGP0783-20 µg, ATGP0783-50 µg, ATGP0783-100 µg, ATGP0783-250 µg, ATGP0783-500 µg, ATGP0783-1 mg, ATGP0783-10, ATGP0783-20, ATGP0783-50, ATGP0783-100, ATGP0783-250, ATGP0783-500, ATGP0783-1

Schwartzberg PL., et al. (2010) Immunity. 32 (2) :253-65.; ; Lenardo MJ., et al (2009) J Clin Invest. 119 (10) :2976-89;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Immunology

NP_002342

O60880

Human

MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP