Recombinant humaan Siglec-10 eiwit

Siglec-10, also known as Sialic acid binding Ig like lectin 10 isoform 3, is a member of the immunoglobulin superfamily that is expressed on eosinophils, neutrophils, monocytes, and B cells. This protein bears an Immuno-receptor tyrosine based inhibitory motif within its cytoplasmic domain. It is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. Also, it binds to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules on the same cell. Recombinant human Siglec-10, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

SIGLEC10, PRO940, SLG2, SIGLEC-10, Sialic acid-binding Ig-like lectin 10 isoform 3, Siglec-like protein 2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

75.6 kDa (678aa)

Siglec10, ATGP3872-10 µg, ATGP3872-20 µg, ATGP3872-50 µg, ATGP3872-100 µg, ATGP3872-250 µg, ATGP3872-500 µg, ATGP3872-1 mg, ATGP3872-10, ATGP3872-20, ATGP3872-50, ATGP3872-100, ATGP3872-250, ATGP3872-500, ATGP3872-1

Zhang P., et al, (2015) J. Surg. Res. 194:107-113.; ; Li N., et al, (2001) J. Biol. Chem. 276:28106-28112.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001164628

Q96LC7

Human

Met17