Recombinant humaan Siglec-2/CD22-eiwit

CD22, also known as B-cell receptor CD22 isoform 1, is a member of the immunoglobulin (Ig) superfamily. It mediates B-cell to B-cell interactions and is involved in the localization of B-cells in lymphoid tissues. This protein plays a positive regulation through interaction with Src family tyrosine kinases and also acts as an inhibitory receptor by recruiting cytoplasmic phosphatases. Recombinant human CD22 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

B-cell receptor CD22 isoform 1, CD22, SIGLEC-2, SIGLEC2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

102.1 kDa (907aa)

Siglec2, CD22, B-cell receptor CD22 isoform 1, CD22, SIGLEC-2, SIGLEC2, ATGP3707-10 µg, ATGP3707-20 µg, ATGP3707-50 µg, ATGP3707-100 µg, ATGP3707-250 µg, ATGP3707-500 µg, ATGP3707-1 mg, ATGP3707-10, ATGP3707-20, ATGP3707-50, ATGP3707-100, ATGP3707-250, ATGP3707-500, ATGP3707-1

Yu SF., et al, (2015) Clin Cancer Res. 21:3298-3306.; ; Lumb S., et al, (2016) J Cell Commun Signal. 10:143-151.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001762

P20273

Human

Asp20