Recombinant humaan Siglec-7/CD328 eiwit

SIGLEC7, also known as sialic acid-binding Ig-like lectin 7 isoform 1, is a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily. The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in sialic acid recognition by other Siglecs. The combination of an extracellular sialic acid binding site and an intracellular ITIM motif suggests that this molecule is involved in trans-membrane regulatory signaling reactions. It exists as a monomer on the cell surface and is expressed on natural killer cells. Recombinant human SIGLEC7, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Sialic acid-binding Ig-like lectin 7 isoform 1, SIGLEC7, AIRM1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

64.2 kDa (577aa)

Siglec7, CD328, Sialic acid-binding Ig-like lectin 7 isoform 1, SIGLEC7, AIRM1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, ATGP3637-10 µg, ATGP3637-20 µg, ATGP3637-50 µg, ATGP3637-100 µg, ATGP3637-250 µg, ATGP3637-500 µg, ATGP3637-1 mg, ATGP3637-10, ATGP3637-20, ATGP3637-50, ATGP3637-100, ATGP3637-250, ATGP3637-500, ATGP3637-1

Crocker., et al. (2001) Trends Immunol. 22:337-342.; ; Nicoll G., et al. (1999) J. Biol. Chem. 274:34089-34095.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cardiovascular

NP_055200

Q9Y286

Human

Ala

QKSNRKD YSLTMQSSVT VQEGMCVHVR CSFSYPVDSQ TDSDPVHGYW FRAGNDISWK APVATNNPAW AVQEETRDRF HLLGDPQTKN CTLSIRDARM SDAGRYFFRM EKGNIKWNYK YDQLSVNVTA LTHRPNILIP GTLESGCFQN LTCSVPWACE QGTPPMISWM GTSVSPLHPS TTRSSVLTLI PQPQHHGTSL TCQVTLPGAG VTTNRTIQLN VSYPPQNLTV TVFQGEGTAS TALGNSSSLS VLEGQSLRLV CAVDSNPPAR LSWTWRSLTL YPSQPSNPLV LELQVHLGDE GEFTCRAQNS LGSQHVSLNL SLQQEYTGKM RPVSGVLL