Recombinant humaan SIRP beta 1/CD172b eiwit

SIRPB1, also known as signal-regulatory protein beta-1 isoform 1, is a type I transmembrane protein of SIRP superfamily. It is an immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein also participates in the recruitment of tyrosine kinase SYK. And it acts as an activating isoform of SIRP alpha molecules that recruit SHP-1 and SHP-2 protein tyrosine phosphatases and activate counterparts, whose engagement couples to protein tyrosine kinases. Recombinant human SIRPB1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Signal-regulatory protein beta-1 isoform 1, SIRPB1, CD172b, SIRP-BETA-1

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

38kDa (348aa)

SIRP b1, CD172b, ATGP3805-10 µg, ATGP3805-20 µg, ATGP3805-50 µg, ATGP3805-100 µg, ATGP3805-250 µg, ATGP3805-500 µg, ATGP3805-1 mg, ATGP3805-10, ATGP3805-20, ATGP3805-50, ATGP3805-100, ATGP3805-250, ATGP3805-500, ATGP3805-1

Liu Y., et al, (2005) J Biol Chem. 280:36132-36140.; ; Gaikwad S., et al, (2009) Am J Pathol. 175:2528-2539.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_006056

O00241

Human

Glu30