Recombinant humaan SLAM/CD150 eiwit

SLAMF1 belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. This protein is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. High-affinity for self-ligand is important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11) -dependent signal transduction operates. Recombinant human SLAMF1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Signaling lymphocytic activation molecule precursor, CD150, CDw150, SLAM

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

26.7 kDa (240aa)

SLAM, CD150, signaling lymphocytic activation molecule precursor, CD150, CDw150, SLAM, ATGP1883-10 µg, ATGP1883-20 µg, ATGP1883-50 µg, ATGP1883-100 µg, ATGP1883-250 µg, ATGP1883-500 µg, ATGP1883-1 mg, ATGP1883-10, ATGP1883-20, ATGP1883-50, ATGP1883-100, ATGP1883-250, ATGP1883-500, ATGP1883-1

Frecha, C., et al. (2011) J. Virol. 85 (12), 5975-5985 ; ; Jordan, M.A., et al. (2011) . Immunol. 186 (7), 3953-3965;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Stem Cell

NP_003028

Q13291

Human

MGSSHHHHHH SSGLVPRGSH MGSASYGTGG RMMNCPKILR QLGSKVLLPL TYERINKSMN KSIHIVVTMA KSLENSVENK IVSLDPSEAG PPRYLGDRYK FYLENLTLGI RESRKEDEGW YLMTLEKNVS VQRFCLQLRL YEQVSTPEIK VLNKTQENGT CTLILGCTVE KGDHVAYSWS EKAGTHPLNP ANSSHLLSLT LGPQHADNIY ICTVSNPISN NSQTFSPWPG CRTDPSETKP