Recombinant humaan SLP-76/LCP2-eiwit

LCP2, also known as lymphocyte cytosolic protein 2, is an intracellular docking protein with a single SH2 recognition domain. It is involved in T-cell antigen receptor mediated signaling. This protein is phosphorylated by ZAP70 leading to NF-AT and IL2 gene activation. Recombinant human LCP2 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Lymphocyte cytosolic protein 2, LCP2, SLP-76, SLP76

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

61.2 kDa (542aa)

SLP76, LCP2, Lymphocyte cytosolic protein 2, LCP2, SLP-76, SLP76, ATGP3706-10 µg, ATGP3706-20 µg, ATGP3706-50 µg, ATGP3706-100 µg, ATGP3706-250 µg, ATGP3706-500 µg, ATGP3706-1 mg, ATGP3706-10, ATGP3706-20, ATGP3706-50, ATGP3706-100, ATGP3706-250, ATGP3706-500, ATGP3706-1

Siggs OM., et al, (2015) J Immunol. 194:2587-2595.; ; Danzer C., et al, (2016) Eur J Immunol. 46:2121-2136.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_005556

Q13094

Human

Ala

MALRNVP FRSEVLGWDP DSLADYFKKL NYKDCEKAVK KYHIDGARFL NLTENDIQKF PKLRVPILSK LSQEINKNEE RRSIFTRKPQ VPRFPEETES HEEDNGGWSS FEEDDYESPN DDQDGEDDGD YESPNEEEEA PVEDDADYEP PPSNDEEALQ NSILPAKPFP NSNSMYIDRP PSGKTPQQPP VPPQRPMAAL PPPPAGRNHS PLPPPQTNHE EPSRSRNHKT AKLPAPSIDR STKPPLDRSL APFDREPFTL GKKPPFSDKP SIPAGRSLGE HLPKIQKPPL PPTTERHERS SPLPGKKPPV PKHGWGPDRR ENDEDDVHQR PLPQPALLPM SSNTFPSRST KPSPMNPLPS SHMPGAFSES NSSFPQSASL PPYFSQGPSN RPPIRAEGRN FPLPLPNKPR PPSPAEEENS LNEEWYVSYI TRPEAEAALR KINQDGTFLV RDSSKKTTTN PYVLMVLYKD KVYNIQIRYQ KESQVYLLGT GLRGKEDFLS VSDIIDYFRK MPLLLIDGKN RGSRYQCTLT HAAGYP