Recombinant humaan Sorteren Nexine 1/SNX1-eiwit

SNX1 (Sorting nexin 1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor. This protein is all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and Insulin receptor tyrosine kinases. Recombinant human SNX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Sorting nexin-1, HsT17379, SNX1A, Vps5

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

48.0 kDa (415aa) confirmed by MALDI-TOF

SNX1, Sorting nexin-1, HsT17379, SNX1A, Vps5, Sorting nexin-1, ATGP0697-10 µg, ATGP0697-20 µg, ATGP0697-50 µg, ATGP0697-100 µg, ATGP0697-250 µg, ATGP0697-500 µg, ATGP0697-1 mg, ATGP0697-10, ATGP0697-20, ATGP0697-50, ATGP0697-100, ATGP0697-250, ATGP0697-500, ATGP0697-1

Kurten RC, et al.. (1996) Science 272 (5264) : 1008-10; ; Parks WT, et al. (2001) J. Biol. Chem. 276 (22) : 19332-9;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl,1mM DTT

Signal Transduction

NP_003090.2

Q13596

Human

TV GITDPEKIGD GMNAYVAYKV TTQTSLPLFR SKQFAVKRRF SDFLGLYEKL SEKHSQNGFI VPPPPEKSLI GMTKVKVGKE DSSSAEFLEK RRAALERYLQ RIVNHPTMLQ DPDVREFLEK EELPRAVGTQ TLSGAGLLKM FNKATDAVSK MTIKMNESDI WFEEKLQEVE CEEQRLRKLH AVVETLVNHR KELALNTAQF AKSLAMLGSS EDNTALSRAL SQLAEVEEKI EQLHQEQANN DFFLLAELLS DYIRLLAIVR AAFDQRMKTW QRWQDAQATL QKKREAEARL LWANKPDKLQ QAKDEILEWE SRVTQYERDF ERISTVVRKE VIRFEKEKSK DFKNHVIKYL ETLLYSQQQL AKYWEAFLPE AKAIS