Recombinant humaan SR-AI/MSR1-eiwit

MSR1, as known as macrophage scavenger receptor types I and II isoform type 1, is single-pass type II membrane protein. Scavenger receptors are a group of membrane receptors that recognize and internalize modified low density lipoproteins (LDLs) and participate in the removal of many foreign substances and waste materials in the living body. Scavenger receptors are categorized into three classes, and class A mainly expressed in macrophage includes three isoforms derived by alternative splicing. This protein, has been suggested to play important roles in macrophage growth, cell adhesion, osteoclast differentiation, and as well as intracellular signaling. Recombinant human MSR1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Macrophage scavenger receptor types I and II isoform type 1, CD204, phSR1, phSR2, SCARA1, SRA, SR-A

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

42.4 kDa (384aa)

SR-AI, MSR1, Macrophage scavenger receptor types I and II isoform type 1, CD204, phSR1, phSR2, SCARA1, SRA, SR-A, ATGP3333-10 µg, ATGP3333-20 µg, ATGP3333-50 µg, ATGP3333-100 µg, ATGP3333-250 µg, ATGP3333-500 µg, ATGP3333-1 mg, ATGP3333-10, ATGP3333-20, ATGP3333-50, ATGP3333-100, ATGP3333-250, ATGP3333-500, ATGP3333-1

Dansako H., et al. (2013) PLoS Pathog. 9:E1003345.; ; Shigeoka M., et al. (2013) Cancer Sci. 104:1112-1119.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_619729

P21757

Human

Ala

KWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ WGTRACSHSE DAGVTCTL