Recombinant humaan ST2/IL1RL1-eiwit

IL1RL1, as known as interleukin-1 receptor-like 1 isoform 1, is and interleukin-1 receptor family glycoprotein that contributes to immune responses. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. Recombinant human IL1RL1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤10 ng/mL with Human IL-33.

Interleukin-1 receptor-like 1, Protein ST2, homolog of mouse growth stimulation-expressed, DER4, T1, FIT-1, ST2L, ST2V, IL33R

Baculovirus

Human

His-Tag

SDS-PAGE, Bioactivity

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤10 ng/mL with Human IL-33.

36 kDa (318aa)

ST2, IL33 R, ATGP3763-10 µg, ATGP3763-20 µg, ATGP3763-50 µg, ATGP3763-100 µg, ATGP3763-250 µg, ATGP3763-500 µg, ATGP3763-1 mg, ATGP3763-10, ATGP3763-20, ATGP3763-50, ATGP3763-100, ATGP3763-250, ATGP3763-500, ATGP3763-1

Yu XX., et al. (2015) Dig. Dis. Sci. 60:1265-1272.; ; Rolland T., et al. (2014) Int. J. Mol. Sci. 15:23227-23239.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Angiogenesis

NP_057316.3

Q01638

Human

Lys19