Recombinant humaan ST6GALNAC5 eiwit

ST6GALNAC5, also known as Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5, is a member of the glycosyltransferase 29 family. This protein is a sialyltransferase involved in the biosynthesis of ganglioside GD1a from GM1b. It is involved in the pathway protein glycosylation, which is part of Protein modification. It’s expression is restricted to the brain normally. It has been identified as a key player in the metastasis of breast cancer cells to the brain by potentially enabling the cancer cells to cross the blood-brain barrier. Recombinant human ST6GALNAC5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5, GD1 alpha synthase, GalNAc alpha-2,6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E, SIAT7E

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

36.4 kDa (316aa)

, ATGP3933-10 µg, ATGP3933-20 µg, ATGP3933-50 µg, ATGP3933-100 µg, ATGP3933-250 µg, ATGP3933-500 µg, ATGP3933-1 mg, ATGP3933-10, ATGP3933-20, ATGP3933-50, ATGP3933-100, ATGP3933-250, ATGP3933-500, ATGP3933-1

Kolter, T. et al. (2002) J. Biol. Chem. 277:25859-25862.; ; Okajima, T. et al. (1999) J. Biol. Chem.274:30557-30562.; ; Harduin-Lepers, A. et al. (2005) Glycobiology 15:805-817.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Tags & Cell Markers

NP_112227

Q9BVH7

Human

Ala39

GGQKERP PQQQQQQQQQ QQQASATGSS QPAAESSTQQ RPGVPAGPRP LDGYLGVADH KPLKMHCRDC ALVTSSGHLL HSRQGSQIDQ TECVIRMNDA PTRGYGRDVG NRTSLRVIAH SSIQRILRNR HDLLNVSQGT VFIFWGPSSY MRRDGKGQVY NNLHLLSQVL PRLKAFMITR HKMLQFDELF KQETGKDRKI SNTWLSTGWF TMTIALELCD RINVYGMVPP DFCRDPNHPS VPYHYYEPFG PDECTMYLSH ERGRKGSHHR FITEKRVFKN WARTFNIHFF QPDWKPESLA INHPENKPVF