Recombinant humaan STAT3-eiwit

STAT3, also known as signal transducer and activator of transcription 3 isoform 1, is a member of the STAT protein family. It is a transcription factor activated in response to cytokine, growth factor, or hormone receptor signaling. Once this protein is activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene and it mediates cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. It also acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells. Recombinant human STAT3 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Signal transducer and activator of transcription 3 isoform 1, STAT3, ADMIO, ADMIO1, APRF, HIES

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

88.8 kDa (776aa)

STAT3, Signal transducer and activator of transcription 3 isoform 1, STAT3, ADMIO, ADMIO1, APRF, HIES, ATGP3823-10 µg, ATGP3823-20 µg, ATGP3823-50 µg, ATGP3823-100 µg, ATGP3823-250 µg, ATGP3823-500 µg, ATGP3823-1 mg, ATGP3823-10, ATGP3823-20, ATGP3823-50, ATGP3823-100, ATGP3823-250, ATGP3823-500, ATGP3823-1

Chakraborty D., et al, (2017) Nat Commun. 8:1130.; ; Han S., et al, (2018) Am J Cancer Res. 8:489-501.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol, 1mM DTT

Signal Transduction

NP_644805.1

P40763

Human

Met1