Recombinant humaan SUFU-eiwit

SuFu (Suppressor of fused homolog) belongs to the SuFu family. This protein is negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. SuFu has been shown to interact with GLI1, GLI3 and PEX26. Recombinant human SuFu protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Suppressor of fused homolog, PRO1280, SuFuH, SuFuXL

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

56.1 kDa (504aa)

SUFU, suppressor of fused homolog, PRO1280, SuFuH, SuFuXL, ATGP1221-10 µg, ATGP1221-20 µg, ATGP1221-50 µg, ATGP1221-100 µg, ATGP1221-250 µg, ATGP1221-500 µg, ATGP1221-1 mg, ATGP1221-10, ATGP1221-20, ATGP1221-50, ATGP1221-100, ATGP1221-250, ATGP1221-500, ATGP1221-1

Dunaeva M, et al. (2003) J. Biol. Chem. 278 (7) : 5116-22.; ; Murone M., et al. (2000) Nat. Cell Biol. 2:310-312

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cancer

NP_057253

Q9UMX1

Human

MAELRPSGAP GPTAPPAPGP TAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY WLGGPDPLDY VSMYRNVGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVQT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDDEDSRS ICIGTQPRRL SGKDTEQIRE TLRRGLEINS KPVLPPINPQ RQNGLAHDRA PSRKDSLESD SSTAIIPHEL IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI TGDMAITFVS TGVEGAFATE EHPYAAHGPW LQILLTEEFV EKMLEDLEDL TSPEEFKLPK EYSWPEKKLK VSILPDVVFD SPLH