Recombinant humaan SUMO3-eiwit

SUMO3, also known as small ubiquitin-related modifier 3, is a member of the SUMO protein family and functions in a manner similar to ubiquitin. However, unlike ubiquitin which targets proteins for degradation, SUMO3 protein participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It regulates amyloid beta generation and may be critical in the onset or progression of Alzheimer's disease. Recombinant human SUMO3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Small ubiquitin-related modifier 3, SMT3A, SMT3H1, SuMO-3, sumo3, sumo 3

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by BCA assay)

> 95% by SDS-PAGE

12.6 kDa (112aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

SUMO3, Small ubiquitin-related modifier 3, SMT3A, SMT3H1, SuMO-3, sumo3, sumo 3, ATGP0750-10 µg, ATGP0750-20 µg, ATGP0750-50 µg, ATGP0750-100 µg, ATGP0750-250 µg, ATGP0750-500 µg, ATGP0750-1 mg, ATGP0750-10, ATGP0750-20, ATGP0750-50, ATGP0750-100, ATGP0750-250, ATGP0750-500, ATGP0750-1

Evdokimov E., et al. (2008), J Cell Sci, 121:4106-13.; ; Tatham MH., et al. (2001) . J Biol Chem. 276:35368-74.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

Ubiquitination

NP_008867

P55854

Human

MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GG