Recombinant humaan supplementfactor B-eiwit

CFB is complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Recombinant human CFB protein, fused to His-tag at N-terminus, was expressed in E. coli.

Complement factor B preproprotein, AHuS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

28.4 kDa (257aa)

Complement Factor B, complement factor B preproprotein, AHuS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2, ATGP2541-10 µg, ATGP2541-20 µg, ATGP2541-50 µg, ATGP2541-100 µg, ATGP2541-250 µg, ATGP2541-500 µg, ATGP2541-1 mg, ATGP2541-10, ATGP2541-20, ATGP2541-50, ATGP2541-100, ATGP2541-250, ATGP2541-500, ATGP2541-1

Mejia J.E., et al (1994) . Hum. Immunol. 39:49-53; ; Schwaeble W., et al (1993) . Immunobiology 188:221-232;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Immunology

NP_001701

P00751

Human

MGSSHHHHHH SSGLVPRGSQ SHMTPWSLAR PQGSCSLEGV EIKGGSFRLL QEGQALEYVC PSGFYPYPVQ TRTCRSTGSW STLKTQDQKT VRKAECRAIH CPRPHDFENG EYWPRSPYYN VSDEISFHCY DGYTLRGSAN RTCQVNGRWS GQTAICDNGA GYCSNPGIPI GTRKVGSQYR LEDSVTYHCS RGLTLRGSQR RTCQEGGSWS GTEPSCQDSF MYDTPQEVAE AFLSSLTETI EGVDAEDGHG PGEQQKR