Recombinant humaan SVIP-eiwit

Small VCP/p97-interacting protein, also known as SVIP, is involved in a variety of cellular processes, including membrane fusion and ubiquitin-dependent protein degradation. SVIP functions as an inhibitor of the endoplasmic reticulum (ER) -associated degradation (ERAD) pathway. Overexpression of SVIP, on the other hand, increased the levels of p62 protein and enhanced starvation-activated autophagy as well as promoted sequestration of polyubiquitinated proteins and p62 in autophagosomes. Recombinant human SVIP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Small VCP/p97-interacting protein, DKFZp313A2432, Small VCP/p97 interacting protein

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

10.8 kDa (100aa) confirmed by MALDI-TOF

SVIP, Small VCP/p97-interacting protein, DKFZp313A2432, Small VCP/p97 interacting protein, ATGP2633-10 µg, ATGP2633-20 µg, ATGP2633-50 µg, ATGP2633-100 µg, ATGP2633-250 µg, ATGP2633-500 µg, ATGP2633-1 mg, ATGP2633-10, ATGP2633-20, ATGP2633-50, ATGP2633-100, ATGP2633-250, ATGP2633-500, ATGP2633-1

Wang Y., et al. (2011) PLoS One. 6 (8) : e24478.; ; Ballar P., et al. (2007) J Bio Chem 23 (47) : 33908-14.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 2mM DTT

Signal Transduction

NP_683691

Q8NHG7

Human

MGSSHHHHHH SSGLVPRGSH MGSMGLCFPC PGESAPPTPD LEEKRAKLAE AAERRQKEAA SRGILDVQSV QEKRKKKEKI EKQIATSGPP PEGGLRWTVS