Recombinant humaan SYT11-eiwit

SYT11 also known as synaptotagmin-11. The protein may be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. A synaptotagmin potentially involved in Parkinson s desease and schizophrenia. Recombinant human SYT11, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Synaptotagmin-11, SYT12, sytXI

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

> 80% by SDS-PAGE

47 kDa (418aa) confirmed by MALDI-TOF

SYT11, Synaptotagmin-11, SYT12, sytXI, ATGP3165-10 µg, ATGP3165-20 µg, ATGP3165-50 µg, ATGP3165-100 µg, ATGP3165-250 µg, ATGP3165-500 µg, ATGP3165-1 mg, ATGP3165-10, ATGP3165-20, ATGP3165-50, ATGP3165-100, ATGP3165-250, ATGP3165-500, ATGP3165-1

Huynh D P., et al. (2003) Hum Mol Genet. 12 (20) :2587-97; ; Glass AS., et al. (2004) J Neural Transm Suppl. (68) :21-8.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 50% glycerol

Neuroscience

NP_689493

Q9BT88

Human

WSCCHQQ AEKKQKNPPY KFIHMLKGIS IYPETLSNKK KIIKVRRDKD GPGREGGRRN LLVDAAEAGL LSRDKDPRGP SSGSCIDQLP IKMDYGEELR SPITSLTPGE SKTTSPSSPE EDVMLGSLTF SVDYNFPKKA LVVTIQEAHG LPVMDDQTQG SDPYIKMTIL PDKRHRVKTR VLRKTLDPVF DETFTFYGIP YSQLQDLVLH FLVLSFDRFS RDDVIGEVMV PLAGVDPSTG KVQLTRDIIK RNIQKCISRG ELQVSLSYQP VAQRMTVVVL KARHLPKMDI TGLSGNPYVK VNVYYGRKRI AKKKTHVKKC TLNPIFNESF IYDIPTDLLP DISIEFLVID FDRTTKNEVV GRLILGAHSV TASGAEHWRE VCESPRKPVA KWHSLSEY