Recombinant humaan T-cel Oppervlakte Glycoproteïne CD4/sCD4 (C-6His)

Source : Human Cells; CD4 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. Mature human CD4 consists of a 371 amino acid extracellular region containing four immunoglobulin-like domains, a 22 aa transmembrane segment, and a 40 aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. CD4 binds directly to MHC class II molecules on antigen presenting cells (10) . This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1.

T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; sCD4

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Ambient

Recombinant Human T-cell Surface Glycoprotein CD4 is produced by our Mammalian expression system and the target gene encoding Lys26-Trp390 is expressed with a 6His tag at the C-terminus.