Recombinant humaan TANK-eiwit

TANK, also known as TRAF (tumor necrosis factor receptor-associated Factor) -interacting protein, is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby proposing that this protein is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1. Recombinant human TANK protein was expressed in E. coli and purified by using conventional chromatography techniques.

TRAF interacting protein TANK isoform b, TRAF interacting protein TANK isoform b, I-TRAF, TRAF2, TRAF interacting protein TANK isoform b I TRAF, ITRAF, TRAF interacting protein, TRAF family member associated NF KAPPA B activator, TRAF family member associated NFKB activator, TRAF interacting protein TANK isoform a

E.coli

Human

Non-Tagged

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

13.6 kDa (119aa) confirmed by MALDI-TOF

TANK, TRAF interacting protein TANK isoform b, TRAF interacting protein TANK isoform b, I-TRAF, TRAF2, TRAF interacting protein TANK isoform b I TRAF, ITRAF, TRAF interacting protein, TRAF family member associated NF KAPPA B activator, TRAF family member associated NFKB activator, TRAF interacting protein TANK isoform a, ATGP0306-10 µg, ATGP0306-20 µg, ATGP0306-50 µg, ATGP0306-100 µg, ATGP0306-250 µg, ATGP0306-500 µg, ATGP0306-1 mg, ATGP0306-10, ATGP0306-20, ATGP0306-50, ATGP0306-100, ATGP0306-250, ATGP0306-500, ATGP0306-1

Rothe M., et al. (1996) Proc Natl Acad Sci u S A. 93 (16) :8241-6.; ; Gatot JS., et al. (2007) J Biol Chem. 282 (43) :31131-46.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0)

Cancer

NP_597841

Q92844

Human

MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI