Recombinant humaan TDP1-eiwit

Tyrosyl-DNA phosphodiesterase 1, also known as TDP1, is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. Recombinant human TDP1, fused to His-tag at N-terminus, was expressed in E. coli.

Tyrosyl-DNA phosphodiesterase 1, FLJ11090, SCAN1, Tyr-DNA phosphodiesterase 1, Tyrosyl DNA phosphodiesterase 1, TDP-1

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

35.8 kDa (318aa)

TDP1, Tyrosyl-DNA phosphodiesterase 1, FLJ11090, SCAN1, Tyr-DNA phosphodiesterase 1, Tyrosyl DNA phosphodiesterase 1, TDP-1, ATGP1950-10 µg, ATGP1950-20 µg, ATGP1950-50 µg, ATGP1950-100 µg, ATGP1950-250 µg, ATGP1950-500 µg, ATGP1950-1 mg, ATGP1950-10, ATGP1950-20, ATGP1950-50, ATGP1950-100, ATGP1950-250, ATGP1950-500, ATGP1950-1

Heilig R., et al. (2003) Nature. 421:601-607; ; The MGC Project Team. (2004) Genome Res. 14:2121-2127;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Epigenomics (Transcription & Translation)

AAH06083

Q9BRS7

Human

MGSSHHHHHH SSGLVPRGSH MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGTHL