Recombinant humaan TGF-beta RII-eiwit

TGFBR2, as known as TGF-beta receptor type-2 isoform B, is a member of the serine and threonine protein kinase family and the TGF beta receptor subfamily. The type-2 receptor binds TGF-beta1 and TGF-beta3 with high affinity, and TGF-beta2 with a much lower affinity. It forms a heterodimeric complex with type1 receptor and is essential for signal transduction. Also, this protein may play an important role in TGF-beta2 binding and signaling in cells lacking TGFBR3. Recombinant human TGFBR2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

TGF-beta receptor type-2 isoform B, TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF beta-RII, TGFR-2

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

43.3 kDa (383aa)

TGF-b RII, TGF-beta receptor type-2 isoform B, TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF beta-RII, TGFR-2, ATGP3355-10 µg, ATGP3355-20 µg, ATGP3355-50 µg, ATGP3355-100 µg, ATGP3355-250 µg, ATGP3355-500 µg, ATGP3355-1 mg, ATGP3355-10, ATGP3355-20, ATGP3355-50, ATGP3355-100, ATGP3355-250, ATGP3355-500, ATGP3355-1

Wrana JL., et al. (1992) Cell 71:1003-1014.; ; Halper B., et al. (2015) Exerc. Immunol. Rev. 21:154-163.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_003233

P37173

Human

Thr23