Recombinant humaan THAP1-eiwit

THAP domain-containing protein 1, also known as THAP1, is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAPtype zinc finger, a conserved DNA-binding domain. It is a DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. THAP1 may also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Recombinant human THAP1protein, fused to His-tag at N-terminus, was expressed in E. coli.

THAP domain-containing protein 1, DYT6

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

27.5 kDa (237aa)

THAP1, THAP domain-containing protein 1, DYT6, ATGP1517-10 µg, ATGP1517-20 µg, ATGP1517-50 µg, ATGP1517-100 µg, ATGP1517-250 µg, ATGP1517-500 µg, ATGP1517-1 mg, ATGP1517-10, ATGP1517-20, ATGP1517-50, ATGP1517-100, ATGP1517-250, ATGP1517-500, ATGP1517-1

Roussigne M., et al. (2003) Oncogene 22:2432-2442.; ; Clouaire T., et al. (2005) Proc Natl Acad Sci. 102:6907-6912.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol, 1mM DTT, 0.2M NaCl

Apoptosis

NP_060575

Q9NVV9

Human

MGSSHHHHHH SSGLVPRGSH MGSHMVQSCS AYGCKNRYDK DKPVSFHKFP LTRPSLCKEW EAAVRRKNFK PTKYSSICSE HFTPDCFKRE CNNKLLKENA VPTIFLCTEP HDKKEDLLEP QEQLPPPPLP PPVSQVDAAI GLLMPPLQTP VNLSVFCDHN YTVEDTMHQR KRIHQLEQQV EKLRKKLKTA QQRCRRQERQ LEKLKEVVHF QKEKDDVSER GYVILPNDYF EIVEVPA