Recombinant humaan TIM-3/HAVCR2-eiwit

HAVCR2, also known as TIM3, belongs to the immunoglobulin superfamily. HACVR2 regulates macrophage activation. It Inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. Recombinant human HAVCR2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, CD366

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

22.7 kDa (206aa)

CD366, Hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domain containing protein 3, T cell immunoglobulin mucin receptor 3, T cell membrane protein 3, T-cell immunoglobulin and mucin domain containing protein 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM 3, TIM3, TIM-3, TIMD 3, TIMD3, TIMD-3, ATGP1875-10 µg, ATGP1875-20 µg, ATGP1875-50 µg, ATGP1875-100 µg, ATGP1875-250 µg, ATGP1875-500 µg, ATGP1875-1 mg, ATGP1875-010, ATGP1875-020, ATGP1875-050, ATGP1875-100, ATGP1875-250, ATGP1875-500, ATGP1875-01M

Sanchez-Fueyo A., et al. (2003) Nat. Immunol. 4:1093-1101; ; Zhu C., et al. (2005) Nat. Immunol. 6:1245-1252;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Immunology

AAH63431

Q8TDQ0

Human

SEVEY RAEVGQNAYL PCFYTPAAPG NLVPVCWGKG ACPVFECGNV VLRTDERDVN YWTSRYWLNG DFRKGDVSLT IENVTLADSG IYCCRIQIPG IMNDEKFNLK LVIKPAKVTP APTLQRDFTA AFPRMLTTRG HGPAETQTLG SLPDINLTQI STLANELRDS RLANDLRDSG ATIRIG