Recombinant humaan TIM-3/HAVCR2-eiwit

HAVCR2, also known as hepatitis A virus cellular receptor 2, is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specificallyidentifies Th1 cells in both mice and human. It interactions with Galectin-9 can alternatively trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity. Recombinant human HAVCR2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Hepatitis A virus cellular receptor 2, HAVCR2, HAVcr-2, KIM-3, Tim-3, TIM3, TIMD-3, TIMD3, FLJ14428, HAVcr-2, Havcr2, HAVR2_HUMAN, Hepatitis A virus cellular receptor 2, Kidney injury molecule 3, KIM 3, KIM3, T cell immunoglobulin and mucin domain containing 3, T cell immunoglobulin mucin 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim 3, TIM-3, TIM3, TIMD-3, TIMD3

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

47.3 kDa (423aa)

CD366, Hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domain containing protein 3, T cell immunoglobulin mucin receptor 3, T cell membrane protein 3, T-cell immunoglobulin and mucin domain containing protein 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM 3, TIM3, TIM-3, TIMD 3, TIMD3, TIMD-3, ATGP3381-10 µg, ATGP3381-20 µg, ATGP3381-50 µg, ATGP3381-100 µg, ATGP3381-250 µg, ATGP3381-500 µg, ATGP3381-1 mg, ATGP3381-010, ATGP3381-020, ATGP3381-050, ATGP3381-100, ATGP3381-250, ATGP3381-500, ATGP3381-01M

Geng H., et al. (2006) J Immunol. 176:1411-1420.; ; Anderson AC., et al. (2006) Curr Opin Immunol. 18:665-669.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_116171

Q8TDQ0

Human

Ala

ADLSEVEYRA EVGQNAYLPC FYTPAAPGNL VPVCWGKGAC PVFECGNVVL RTDERDVNYW TSRYWLNGDF RKGDVSLTIE NVTLADSGIY CCRIQIPGIM NDEKFNLKLV IKPAKVTPAP TRQRDFTAAF PRMLTTRGHG PAETQTLGSL PDINLTQIST LANELRDSRL ANDLRDSGAT IRIGLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH