Recombinant humaan TIMP-1-eiwit
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
TIMP1 also known as metalloproteinase inhibitor 1. The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4. Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form. The complex of latent MMP-2 (pro-MMP-2) with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP. The role of the pro-MMP-9/TIMP-1 complex is still unknown. Recombinant human TIMP1, fused to His-tag at N-terminus, was expressed in E. coli.
Metalloproteinase inhibitor 1, EPA, EPO, HCI, CLGI, TIMP
E.coli
Human
His-Tag
SDS-PAGE, Denatured
0.25 mg/mL (determined by Bradford assay)
> 90% by SDS-PAGE
23 kDa (205aa)
TIMP1, Metalloproteinase inhibitor 1, EPA, EPO, HCI, CLGI, TIMP, ATGP3013-10 µg, ATGP3013-20 µg, ATGP3013-50 µg, ATGP3013-100 µg, ATGP3013-250 µg, ATGP3013-500 µg, ATGP3013-1 mg, ATGP3013-10, ATGP3013-20, ATGP3013-50, ATGP3013-100, ATGP3013-250, ATGP3013-500, ATGP3013-1
Brew K., et al. (2000) Biochim Biophys Acta 1477 (1-2) : 267-83.
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Cardiovascular
NP_003245
P01033
Human
MGSSHHHHHH SSGLVPRGSH MCTCVPPHPQ TAFCNSDLVI RAKFVGTPEV NQTTLYQRYE IKMTKMYKGF QALGDAADIR FVYTPAMESV CGYFHRSHNR SEEFLIAGKL QDGLLHITTC SFVAPWNSLS LAQRRGFTKT YTVGCEECTV FPCLSIPCKL QSGTHCLWTD QLLQGSEKGF QSRHLACLPR EPGLCTWQSL RSQIA
Beschrijving
TIMP1 also known as metalloproteinase inhibitor 1. The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (T
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