Recombinant humaan TNFRSF16/NGFR-eiwit

NGFR, also known as tumor necrosis factor receptor superfamily member 16, is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle. It plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. They are low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. It can mediate cell survival as well as cell death of neural cells. Recombinant human NGFR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 16, TNFRSF16, TNFR superfamily member 16, p75NTR, p75 (NTR), NGFR, Nerve growth factor receptor, Gp80-LNGFR, CD271

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

24.6 kDa (230aa)

NGF TNFRSF16, NGFR, CD271, Gp80-LNGFR, p75 (NTR), p75NTR, TNFRSF16, ATGP3197-10 µg, ATGP3197-20 µg, ATGP3197-50 µg, ATGP3197-100 µg, ATGP3197-250 µg, ATGP3197-500 µg, ATGP3197-1 mg, ATGP3197-10, ATGP3197-20, ATGP3197-50, ATGP3197-100, ATGP3197-250, ATGP3197-500, ATGP3197-1

Baeza-Raja B., et al. (2012) J. Neurosci. 33:10221-10234.; ; Irie S., et al. (1999) FEBS Lett. 29:460:191-198.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_002498.1

P08138

Human