Recombinant humaan TRAILR1/TNFRSF10A eiwit

TNFRSF10A, also known as tumor necrosis factor receptor superfamily member 10A, is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Recombinant human TNFRSF10A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 10A, TRAILR-1, TRAILR1, TRAIL receptor 1, TNFRSF10A, TNF-related apoptosis-inducing ligand receptor 1, DR4, Death receptor 4, CD261, APO2

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

23.9 kDa (224aa)

TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A, TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, ATGP3695-10 µg, ATGP3695-20 µg, ATGP3695-50 µg, ATGP3695-100 µg, ATGP3695-250 µg, ATGP3695-500 µg, ATGP3695-1 mg, ATGP3695-10, ATGP3695-20, ATGP3695-50, ATGP3695-100, ATGP3695-250, ATGP3695-500, ATGP3695-1

Pan G., et al, (1997) Science 276:111-113.; ; Kuang A.A., et al, (2000) J. Biol. Chem. 275:25065-25068.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

NP_003835.3

O00220

Human

Ala24