Recombinant humaan transthyretin/prealbumine-eiwit

Prealbumin, also known Transthyretin, is a tetrameric human plasma protein that is synthesized mainly in the liver. This protein transports the thyroid hormone thyroxine (T4) and retinol (Vitamin A) . It is the best indicator of protein-energy malnutrition because it has a circulating half life of 2 days and responds rapidly to changes in nutritional status. Also point-mutations of its gene are known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC) . Recombinant human Prealbumin was expressed in E. coli and purified by using conventional chromatography.

TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein.

E.coli

Human

Non-Tagged

SDS-PAGE

1 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

13.8 kDa (128aa) confirmed by MALDI-TOF

Transthyretin, Prealbumin, TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein., ATGP0456-10 µg, ATGP0456-20 µg, ATGP0456-50 µg, ATGP0456-100 µg, ATGP0456-250 µg, ATGP0456-500 µg, ATGP0456-1 mg, ATGP0456-10, ATGP0456-20, ATGP0456-50, ATGP0456-100, ATGP0456-250, ATGP0456-500, ATGP0456-1

Ando Y., et al. (2009) Rinsho Byori. 57 (3) :228-35.; ; Shenkin A., et al. (2006) Clin Chem. 52 (12) :2177-9.;

Abdirama D, et al. Nuclear antigen-reactive CD4 + T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys. (Kidney Int. 2021) {https://pubmed.ncbi.nlm.nih.gov/32592813/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_000362.1

P02766

Human

MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE