Recombinant humaan TRIB3-eiwit

TRIB3, also known as tribbles pseudokinase 3, is a putative protein kinase that is induced by the transcription factor NF-kappaB. This protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, it can negatively regulate the cell survival serine-threonine kinase AKT1. Recombinant human TRIB3 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Tribbles homolog 3, Tribbles homolog 3, C20orf97, NIPK, SINK, SKIP3, TRB3

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

42.0 kDa (381aa)

TRIB3, Tribbles homolog 3, Tribbles homolog 3, C20orf97, NIPK, SINK, SKIP3, TRB3, ATGP2922-10 µg, ATGP2922-20 µg, ATGP2922-50 µg, ATGP2922-100 µg, ATGP2922-250 µg, ATGP2922-500 µg, ATGP2922-1 mg, ATGP2922-10, ATGP2922-20, ATGP2922-50, ATGP2922-100, ATGP2922-250, ATGP2922-500, ATGP2922-1

Du K. et al. (2003) Science. 300:1574-1577.; ; Hegedus Z. et al. (2006) Cell Mol Life Sci. 63:1632-1641.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Signal Transduction

NP_066981

Q96RU7

Human

MGSSHHHHHH SSGLVPRGSH MGSMRATPLA APAGSLSRKK RLELDDNLDT ERPVQKRARS GPQPRLPPCL LPLSPPTAPD RATAVATASR LGPYVLLEPE EGGRAYQALH CPTGTEYTCK VYPVQEALAV LEPYARLPPH KHVARPTEVL AGTQLLYAFF TRTHGDMHSL VRSRHRIPEP EAAVLFRQMA TALAHCHQHG LVLRDLKLCR FVFADRERKK LVLENLEDSC VLTGPDDSLW DKHACPAYVG PEILSSRASY SGKAADVWSL GVALFTMLAG HYPFQDSEPV LLFGKIRRGA YALPAGLSAP ARCLVRCLLR REPAERLTAT GILLHPWLRQ DPMPLAPTRS HLWEAAQVVP DGLGLDEARE EEGDREVVLY G