Recombinant humaan TROP-2-eiwit

TACSTD2, also known as tumor-associated calcium signal transducer 2, is an identified cell surface glycoprotein highly expressed by human carcinomas. It is detected in normal kidney, lung, ovary and testis, similarly to the human gene. It is undetectable in undifferentiated spindle cell carcinomas, this suggests a preferential expression at early stages of tumor progression. Its inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway. Recombinant human TACSTD2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor-associated calcium signal transducer 2, TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

28.6 kDa (253aa)

TROP2, Tumor-associated calcium signal transducer 2 , TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, ATGP3463-10 µg, ATGP3463-20 µg, ATGP3463-50 µg, ATGP3463-100 µg, ATGP3463-250 µg, ATGP3463-500 µg, ATGP3463-1 mg, ATGP3463-10, ATGP3463-20, ATGP3463-50, ATGP3463-100, ATGP3463-250, ATGP3463-500, ATGP3463-1

Wang XD., et al. (2015) Mol Med Rep. 12:865-870.; ; Ripani E., et al. (1998) Int J Cancer. 76:671-676.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cancer

NP_002344.2

P09758

Human

Ala

QDNCTCP TNKMTVCSPD GPGGRCQCRA LGSGMAVDCS TLTSKCLLLK ARMSAPKNAR TLVRPSEHAL VDNDGLYDPD CDPEGRFKAR QCNQTSVCWC VNSVGVRRTD KGDLSLRCDE LVRTHHILID LRHRPTAGAF NHSDLDAELR RLFRERYRLH PKFVAAVHYE QPTIQIELRQ NTSQKAAGDV DIGDAAYYFE RDIKGESLFQ GRGGLDLRVR GEPLQVERTL IYYLDEIPPK FSMKRLT