Recombinant humaan Troponine C2/TNNC2-eiwit

Troponin C, skeletal muscle, also known as TNNC2, is the central regulatory protein of striated muscle contraction, and modulates the Ca2+-activation characteristics of muscle fibers. Troponin has 3 subunits, Troponin I (Tn-1), Troponin T (Tn-T) and Troponin C (Tn-C) . Tn-I subunit inhibits actomyosin ATPase and Tn-T subunit binds tropomyosin and Tn-C, while Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. Mutations in all components of this complex have been associated with skeletal muscle disease. Recombinant human Troponin C was expressed in E. coli and purified by using conventional chromatography.

Troponin C2, Troponin C1 slow, Troponin C type 2 (fast), Troponin C type 1 (slow), Troponin C skeletal muscle, Troponin C, TNNC2, TNNC, Slow skeletal and cardiac muscles, Skeletal troponin C, Skeletal muscle TNNC1, Fast skeletal type, Fast skeletal muscle troponin C, FAP85, CFAP85, Cardiac troponin C

E.coli

Human

Non-Tagged

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

18.1 kDa (160aa) confirmed by MALDI-TOF

Troponin C (1160aa), Troponin C skeletal muscle, Troponin C, skeletal muscle, TNNC2, Troponin C, skeletal muscle TNNC1, Cardiac troponin C, TNNC, Troponin C1 slow, Fast skeletal muscle troponin C, Skeletal troponin C, Troponin C type 1 (slow), Troponin C type 2 (fast), Troponin C, slow skeletal and cardiac muscles, ATGP0332-10 µg, ATGP0332-20 µg, ATGP0332-50 µg, ATGP0332-100 µg, ATGP0332-250 µg, ATGP0332-500 µg, ATGP0332-1 mg, ATGP0332-10, ATGP0332-20, ATGP0332-50, ATGP0332-100, ATGP0332-250, ATGP0332-500, ATGP0332-1

Prentice H., et al. (1994) . J Mol Cell Cardial. 26 (10) :1393-401. ; ; Gahlmann R., et al. (1988) . J Mol Biol. 201 (2) :379-91. ; ; Li Y., et al. (2008) . Hereditas. 145 (6) :274-82.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 100 mM NaCl, 10% glycerol

Cytoskeleton

NP_003270.1

P02585

Human

MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ