Recombinant humaan TSC22D3-eiwit

TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

TSC22 domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

17.2 kDa (157aa) confirmed by MALDI-TOF

TSC22D3, TSC22 domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R, ATGP1760-10 µg, ATGP1760-20 µg, ATGP1760-50 µg, ATGP1760-100 µg, ATGP1760-250 µg, ATGP1760-500 µg, ATGP1760-1 mg, ATGP1760-10, ATGP1760-20, ATGP1760-50, ATGP1760-100, ATGP1760-250, ATGP1760-500, ATGP1760-1

Asselin-Labat M.-L., et al. (2004) Blood. 104:215-223; ; Berrebi D., et al. (2003) Blood. 101:729-738

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Epigenomics (Transcription & Translation)

NP_004080

Q99576

Human

MNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV